- LIFE THREATENING ARRHYTHMIAS INCLUDING VENTRICULAR FIBRILLATION OR PULSELSS VENTRICULAR TACHYCARDIA UNRESPONSIVE TO SHOCK, CPR AND VASOPRESSOR
- Recurrent, unstable ventricular tachycardia
- For ventricular fibrillation or ventricular tachycardia unresponsive to CPR, shock and vasopressor:
- Dose #1: 300 mg. IV or IO push
- Dose #2: If needed, give 150 mg. IV/IO push.
- Life threatening arrhythmias
- Rapid infusion: 150 mg IV over 10 minutes
- May repeat rapid infusion every 10 minutes as needed.
- Slow infusion: 360 mg IV over 6 hours (1 mg/min)
- Maintenance infusion: 540 mg IV over 18 hours (0.5 mg/min)
- Maximum cumulative dose: 2.2 g IV over 24 hours
- Do not give with other drugs that prolong the QT interval (procainamide)
- Rapid infusion may cause hypotension
- Cumulative doses of greater than 2.2 grams over 24 hours given with multiple dosing are associated with hypotension.
- The half-life may be up to 40 days, so elimination time is extremely long.
- Multiple complex drug interactions are possible.
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