

Step 1:
Return of Spontaneous Circulation (ROSC)
Step 2:
Optimize ventilation and oxygenation
• Maintain oxygen saturation≥94%
• Consider advanced airway and waveform capnography
• Do not hyperventilate
Step 3:
Treat hypotension (SBP <90 mm Hg)
• IV/IO bolus
• Vasopressor infusion
• Consider treatable causes
• 12-Lead ECG
Step 4:
Follow commands?
Step 5:
Consider induced hypothermia
Step 6:
STEMI OR high suspicion of AMI
Step 7:
Coronary reperfusion
Step 8:
Advanced critical care
Yes No
Yes No
Doses/Details
Ventilation/Oxygenation
Avoid excessive ventilation. Start at 10-12 breaths/min and titrate to target PETCO2 of 35-40 mm Hg. When feasible, titrate FlO2 to minimum necessary to achieve SpO2 ≥94%.
IV Bolus
1-2 L normal saline or lactated Ringer’s. If inducing hypothermia, may use 4⁰C fluid.
Epinephrine IV Infusion:
0.1-0.5 mcg/kg per minute (in 70-kg adult: 7-35 mcg per minute)
Dopamine IV Infusion:
5-10 mcg/kg per minute
Norepinephrine IV Infusion:
0.1-0.5 mcg/kg per minute (in 70-kg adult: 7-35 mcg per minute)
Reversible Causes
• Hypovolemia
• Hypoxia
• Hydrogen ion (acidosis)
• Hypo-/hyperkalemia
• Hypothermia
• Tension pneumothorax
• Tamponade, cardiac
• Toxins
• Thrombosis, pulmonary
• Thrombosis, coronary
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